SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation.

J Virol · 2021 · PMC8104116 · PMID 33608407

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a slight trendno p-value reported

SARS2-S1/S2-mut exhibited an interesting behavior in that it exhibited reduced fusion activity when either ACE2 or TMPRSS2 was absent but was fully fusion competent under all conditions in between, with probably a slight trend toward highest activity with comparatively low TMPRSS2 levels, and so it was similar in that respect to SARS1-S.

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