Effects of Screenings in Reducing Colorectal Cancer Incidence and Mortality Differ by Polygenic Risk Scores.

Clin Transl Gastroenterol · 2021 · PMC8104134 · PMID 33955373

Europe PMC DOI

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marginal significanceno p-value reported

We did find that in the younger age group (age 50–60 years), there is a significant interaction between screening and PRS ( P interaction , 0.043 for incidence and marginal significance of 0.092 for mortality), suggesting that a CRC screening at a younger age might only benefit individuals with intermediate or higher genetic risk.

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