Differential impacts of hemolysis on coagulation parameters of blood samples: A STROBE-compliant article.

There were highly significant differences among the three groups ( p < 0.0001) (Fig. 1 B). 3.3 Association of cell-free hemoglobin concentrations at different degrees of simulated hemolysis with corresponding values of coagulation parameters Spearman correlation analysis demonstrated a significant decrease in the values of APTT ( P < .001), fibrinogen ( P = .007), D-dimer ( P < .001), and protein C ( P = .014) with an increasing degree of simulated hemolysis (Fig. 2 ).

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