Early development and functional properties of tryptase/chymase double-positive mast cells from human pluripotent stem cells.

J Mol Cell Biol · 2021 · PMC8104937 · PMID 33125075

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As shown in Figure 4A , with activation of CRA1 (anti-FcεRI antibody) via FcεRI, IgE-sensitized CB CD34 + -MCs released relatively small proportions of histamine (maximum 38% histamine release), whereas the other two types of MCs exhibited stronger and highly significant histamine release, with a maximum of 60% for coculture D14 CD34 + CD45 + -MCs and 76% for coculture D8 CD34 + c-kit + -MCs.

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