Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.

It was found that, at the 8th week after ovariectomization, compared with mice without hepcidin overexpression, the number of osteoblasts showed a decreasing trend in hepcidin overexpression mice, but there was no significant statistical difference ( Figure 2C , 2D ).

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