Long-term maturation of human cortical organoids matches key early postnatal transitions.

Nat Neurosci · 2021 · PMC8109149 · PMID 33619405

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highly significantp = 1.57e −10actually significant

Nevertheless, we observed a highly significant, monotonic correlation between the length of differentiation of the hCS in vitro and their predicted methylation age (r = +0.76, p = 1.57e −10 ; Figure 1a ), consistent with continuous and progressive maturation of these cultures over time.

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