highly significantP ‐value < 10E−10
When we compared the hu.MAP 2.0 interactions to the most co‐expressing pairs in Kustatcher et al , we see a highly significant overlap ( P ‐value < 10E−10, hypergeometric test) indicating a high degree of consistency between the orthogonal datasets. hu.MAP 2.0 complex map Once we confirmed our protein interaction network was of high quality, we then clustered this network using a parameterized two‐stage clustering algorithm to identify highly connected proteins which represent protein complexes.