98 Contradictory findings regarding IFN-I responses and COVID-19 severity might be explained by differences in sampling time and tissue sampled, and resolving them would be highly significant as recombinant IFN-I is currently investigated as potential COVID-19 treatment. 99 Progression to severe clinical picture is associated with hyperactivation of the immune system manifested by increased levels of inflammatory cytokines in circulation, also called “cytokine storm”. 40 Levels of C-rea
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