A Blinded Randomized Trial Comparing 2 Needle Gauges for Fine-Needle Biopsy of Thyroid Nodules.

11 In a meta-analysis of studies examining needle gauge and technique, Moss et al concluded that there was a nonsignificant trend toward a reduction in the relative risk of ND cytopathology when smaller needles were used. 12 Our study found a clear statistically significant difference, with the 27G needle yielding much fewer ND results.

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