Risk Stratification and Clinical Utility of Polygenic Risk Scores in Ophthalmology.

However, SNPs with borderline significance not meeting the genome-wide threshold may still be associated with disease, 16 , 19 thus a PRS may improve the estimate of the “true” genetic risk and predictive power by including a larger number of SNPs using more lenient statistical thresholds. 18 To account for correlated and coinherited SNPs (

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