Biophysical Compatibility of a Heterotrimeric Tyrosinase-TYRP1-TYRP2 Metalloenzyme Complex.

The sequence alignment between the TYR residues 1–510 and the corresponding intramelanosomal domain sequence from the crystallographic structure of TYRP1 (residues 25–471) was calculated to have highly significant 3D structural similarity [sequence identity 45%, p = 10 −40 ( Abagyan and Batalov, 1997 ), Figure 1 ].

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All of the parallel 3-helix bundles found as templates for our model were from viruses and mediated membrane fusion, which may be significant in this case.

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