Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord.

With that aim, we focused on four genes: three associated with at least one highly significant (top 10% lowest P -value) Tlx3 binding event and with enriched expression in superficial dorsal horn ( Robo2 , Lphn2 , and Gpr26 ), as determined by the analysis of expression patterns in the literature and public in situ hybridization database GenePaint 6 ( Li et al., 2006 ; Eichele and Diez-Roux, 2011 ); and one not associated with Tlx3 binding ( Zic2 ) to function as negative control ( Figure 3A ).

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