Barely Significant
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Investigating the Relationship Between IGF-I, IGF-II, and IGFBP-3 Concentrations and Later-Life Cognition and Brain Volume.

J Clin Endocrinol Metab · 2021 · PMC8118585 · PMID 33631000

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In the subjects with imaging available, higher concentrations of IGF-I at age 60 to 64 were directionally associated with a 8% lower WMHV at age 71 years (95% CI −19%, 3%, P = 0.142), yet did not reach conventional levels of significance.

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