Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis.

Front Immunol · 2021 · PMC8118696 · PMID 33995417

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highly significantno p-value reported

In these patients the change in itaconate levels showed highly significant negative correlation with changes in disease activity following the initial 3 months of conventional disease-modifying anti-rheumatic drug (DMARD) therapy, with a decrease in overall disease activity (DAS44) or measures of inflammation (CRP and ESR) being associated with an increase in plasma itaconate ( 137 ).

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