Our finding of highly significant enrichments of multiple IFN regulatory factors (IRFs) and NF-κB as the primary regulators of cluster 9 expression adds further credence to results of the above GO analysis and previous in vitro evidence of an inverse relationship between IRF7 and HPSE gene expression ( 11 ).
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Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival.
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