Unbiased de novo motif analysis identified highly significant enrichment of the EGR2 motif within these ChIP-seq peaks (Supplementary Table 2 ), with the identified motif closely matching the consensus EGR2 motif (Supplementary Fig. 6d ).
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Antigen-driven EGR2 expression is required for exhausted CD8<sup>+</sup> T cell stability and maintenance.
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