Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature.

This may be significant, since supplementation with ω-3 PUFAs resulted in increased levels of EPEA and DHEA in rat brain at the expense of anandamide [ 180 , 181 ] and because the CB2 receptor is thought to signal anti-inflammatory effects in both peripheral and CNS immune cells [ 182 ]. 3.

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