Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic of Metabolic Syndrome and Premature Coronary Heart Disease-Family Study.

When proportioned to the levels of abundant linoleic acid-carrying PC (16:0/18:2) and PC (18:0/18:2) which were linked inversely with metabolic syndrome in the HDL3 fraction (see section above), the difference of these ratios remained highly significant in both HDL fractions and in respect to both premature CHD and metabolic syndrome: the decreases of the ratios of PC (16:0/18:2) to PC (18:0/20:3) and of PC (18:0/18:2) to PC (18:0/20:3) ranged from 14% to 25% in the HDL2 fraction and from 15% to 22% in the HDL3 fraction in affected subjects ( Table S1 , Figure 1 ).

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