Mitigating the Adverse Effects of Polychlorinated Biphenyl Derivatives on Estrogenic Activity via Molecular Modification Techniques.

As explained in Table 7 , under the same external conditions of the 7 types of PCB-44 derivatives, only the absolute value of the binding energy of PCB-44-6 and PCB-44-7 to the oestrogen receptor showed a decreasing trend; the reduction rates were 13.77% to 33.66% and 19.99% to 31.68%, respectively, indicating that the anti-oestrogenic activity of these two molecules was expressed to a much lesser extent than the standard molecule PCB-44.

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