Variability in commercially available deformable image registration: A multi-institution analysis using virtual head and neck phantoms.

Such small differences may not be clinically significant when considering contour propagation, but may be significant when reviewing dose accumulation, especially in high‐dose gradient regions. 16 A surprising finding was that, on average, the differences in TRE between institutions using the same software were not statistically significant when accounting for the change in MIM versions as shown in Tables 4 , 5 , 6 .

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