A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure.

Sci Rep · 2021 · PMC8131754 · PMID 34006920

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a possible trendno p-value reported

A possible trend seems to be that the PROSS algorithm prefers solvent exposed residues since 83% of the substituted AAs are located at the protein’s surface (Fig. 1 b).

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