A Researcher's Guide to the Measurement and Modeling of Puberty in the ABCD Study<sup>®</sup> at Baseline.

Front Endocrinol (Lausanne) · 2021 · PMC8131843 · PMID 34025573

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likely to be significantno p-value reported

Pre-specifying the smallest effect size of interest ( 47 ) and/or employing the use of discovery samples for model-fitting and replication or holdout samples for model testing might also be useful ( 48 ), especially because small effects are likely to be significant when sample sizes are large.

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