Isothiourea-catalysed enantioselective Michael addition of N-heterocyclic pronucleophiles to α,β-unsaturated aryl esters.

27 The incorporation of a β-ester substituent gave product 81 in moderate dr but excellent overall yield and enantioenrichment, indicating that the hybridisation of the β-substituent may be significant in determining diastereocontrol.

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