NR led to a marginally significant increase in female lifespan at one site, but this was balanced by a marginally significant decline in female lifespan at another (as well as a marginally significant decline in lifespans of males at a single site) (Table 2 ).
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17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex.
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