Were Ancestral Proteins Less Specific?

Mol Biol Evol · 2021 · PMC8136485 · PMID 33528559

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an overall trendno p-value reported

Our work does not rule out a trend of increased intrinsic specificity over deep evolutionary time, but it does caution against interpreting changes in biological specificity as evidence for an overall trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.