ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion.

Nucleic Acids Res · 2021 · PMC8136815 · PMID 34009296

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highly significantP < 10E–50actually significant

Comparison with our dataset of ERG-regulated ASEs revealed that a highly significant proportion (132/410; 32.2%, P < 10E–50) of ERG-regulated ASEs were also sensitive to RBFOX2 knockdown (Figure 3D ).

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