highly significantp < 0.05
Differences between each group were determined to be significant using one-way ANOVA (* p < 0.05, significant; ** p < 0.01, *** p < 0.001, highly significant, the Multiple Comparisons by Tukey) or analyzed by unpaired two-tailed t -test (* p < 0.05, significant; ** p < 0.01, *** p < 0.001, highly significant).