24 There was no correlation between serum AA levels and HAM-D scores in depressed patients 25 while rather weak (rho = −0.230) and marginally statistically significant ( P = .050, Spearman’s rank test) correlation of HAM-D scores with plasma levels of AA (but not Kyn, 3HK, KYNA, and XA) were reported in medicated MDD patients before ECT treatment. 26 AA formation from Kyn is catalyzed by Kynase .
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Plasma Anthranilic Acid and Leptin Levels Predict HAM-D Scores in Depressed Women.
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The present data on strong and highly significant correlation of AA/leptin plasma levels with HAM-D scores warrant further evaluation of plasma leptin and AA measurement as an objective laboratory test for the assessment of depression severity in female MDD patients.