VSIG4(+) peritoneal macrophages induce apoptosis of double-positive thymocyte via the secretion of TNF-α in a CLP-induced sepsis model resulting in thymic atrophy.

The finding of VivoTracker positive cells in the thymus of sham mice may be significant in a point that it indicates potential migration of peritoneal macrophages to thymus under physiological conditions, which increases more than 10-fold (6.21/0.613) upon CLP induction (Fig. 2h ).

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