highly significantp < 2.2E − 308
Although the number of shared hyperDMRs ( n = 2760) drastically outnumbered the shared hypoDMRs ( n = 195), both were highly significant ( p < 2.2E − 308 and p < 6.0E − 199, respectively, hypergeometric tests, using as background 500 bp genomic regions with at least one CpG and MeDIP and/or MRE signal in at least one sample) (Methods and Fig. 1a ).