Genome-Wide Epigenetic Landscape of Lung Adenocarcinoma Links HOXB9 DNA Methylation to Intrinsic EGFR-TKI Resistance and Heterogeneous Responses.

JCO Precis Oncol · 2021 · PMC8140798 · PMID 34036228

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hedged sentences

0.0001

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP = .0001actually significant

Comparison with the percentage of probes in the Illumina Infinium HumanMethylation450 BeadChip annotated to TFs (34,129/482,421; 7.07%) revealed that the enrichment was highly significant (binomial P = .0001).

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an increasing trendno p-value reported

We examined the changes in the proportion of each category during our probe selection and found an increasing trend in CpG islands and the gene promoter region TSS1500 (between 1,500 bp and 200 bp upstream of the transcription start site).

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