highly significantp = 2 × 10 –24
Compared with the expected overlap (based on a random distribution of mutations and polymorphisms), the overlap between polymorphisms in all of our MA lines and populations with those of natural variants is highly significant (Fisher’s exact test: SNV, p = 2 × 10 –24 ; indel, p = 1 × 10 –12 ; Fig. 8 ).