Discussion Using our method to detect evidence for iron dyshomeostasis in RNA-seq data, we found highly significant alteration of the expression of genes with IREs in the 5’UTRs of their mRNAs in 4-month-old park7 −/− brains.
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Loss of park7 activity has differential effects on expression of iron responsive element (IRE) gene sets in the brain transcriptome in a zebrafish model of Parkinson's disease.
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