Barely Significant
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Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance.

Diagnostics (Basel) · 2021 · PMC8146862 · PMID 33925181

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an increasing trendno p-value reported
Due to an increasing trend of ESBL-positivity in E. coli and consequential multidrug-resistant phenotypes, guidelines for the management of UTIs were updated.

also in 63,971 other papers

a worrying trendno p-value reported
In that study, 50% of isolates were resistant to both imipenem and meropenem, with some isolates expressing the bla NDM-1 gene [ 59 ], which indicates a worrying trend. 4.

also in 642 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.