Due to an increasing trend of ESBL-positivity in E. coli and consequential multidrug-resistant phenotypes, guidelines for the management of UTIs were updated.
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Mechanisms of Resistance in Gram-Negative Urinary Pathogens: From Country-Specific Molecular Insights to Global Clinical Relevance.
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In that study, 50% of isolates were resistant to both imipenem and meropenem, with some isolates expressing the bla NDM-1 gene [ 59 ], which indicates a worrying trend. 4.