Analysis of a Routinely Used Commercial Anti-Chikungunya IgM ELISA Reveals Cross-Reactivities with Dengue in Brazil: A New Challenge for Differential Diagnosis?

In anti-DENV IgM positive samples (Group E), the anti-chikungunya virus IgM ELISA showed cross-reactivity in 46.7% (28/60) of the cases ( Table 1 ), and the differences observed in the OD when those were compared to the negative samples were highly significant ( p < 0.0001) ( Figure 1 ).

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