highly significantp < 0.001
The reliability of RNA-seq data was validated by qRT-PCR detection of 10 randomly selected up- and down-CRGs using gene-specific primers ( Supplementary Table S1 ), showing a highly significant correlation (R 2 = 0.96, p < 0.001) between the results of RNA-seq and qRT-PCR ( Figure 2 C,D).