The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion.

Importantly, we detected a highly significant increase in the number of cells positive for activated Caspase 3 (AC3) cells ( Fig. 1 H ) and the numbers of GFAP-positive astrocytes and Iba1-positive microglial cells in the cerebral cortex of Wdr91 cKO mice compared with WT ( Fig.

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