Synergistic Effect of Perampanel and Temozolomide in Human Glioma Cell Lines.

An analysis of cell cycle perturbations showed that, in U87 and U138 cell lines, although with some differences (250 μM at 48 h for U87 and 100 μM at 24 h for U138), treatment with perampanel resulted in a barely significant accumulation of cells in the G1 phase ( Figure 3 ).

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