Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice.

5 a and b). The GO terms and KEGG pathways analyses showed that there is a significant difference between wild-type and KO mice, in particular, the molecular signaling in KO mice was highly significant in cell adhesion, extracellular matrix organization, and regulation of cell proliferation.

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Overall, these findings suggest that hub genes may play a critical role in cancer development and may be a useful marker for predicting the survival of cancer patients and may be significant in determining treatment outcomes.

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