As shown in Figures 8E, F , there was an increasing trend for the expression level of HOXB9 in different cells of brain metastatic BrMs.
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Phenotypic Plasticity Conferred by the Metastatic Microenvironment of the Brain Strengthens the Intracranial Tumorigenicity of Lung Tumor Cells.
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Simultaneously, all the brain metastases were almost significantly stained with Ki67, an intrinsic marker of cell proliferation, and the knockdown of HOXB9 led to the reduction of Ki67 in these loci ( Figure 8H ).