a trend towards significancep = 0.0574
However, the change in CES score between inclusion and the end of the study period was dependent on the ATE cluster ( p = 0.039) and ELA ( p = 0.0217), with a trend towards significance for diabetes ( p = 0.0574), sex ( p = 0.062), and pre-existing rheumatic disease ( p = 0.072) ( Supplementary Table S4 ; Figure 5 C).