However, although an increasing trend was identified in a cohort from India [ 56 ], several studies report a decrease on K65R levels over the years in other countries [ 48 , 57 , 58 , 59 , 60 ].
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Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.
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The most common mutation across the years was M184V ( Figure 1 ), notwithstanding a decreasing trend and a significant decrease between 2015 (68.29%, n = 1874) and 2016 (53.21%, n = 2684) ( p < 0.001) ( Table 2 ).