Correlation of LINE-1 Hypomethylation With Size and Pathologic Extent of Dysplasia in Colorectal Tubular Adenomas.

Based on a preliminary comparison of LINE-1, the relative percent methylation of 72% in diminutive polyps (<6 mm) with a SD of 6%, a desired power of 80%, and a type 1 error rate of 5%, and the assumption that ≥4% difference in percent methylation could be considered significant among an alternative sized adenoma group (polyps >6 mm); a sample size ≥36 per group was derived to compare polyps across size (<6 mm vs larger in size vs 6–9 mm in size vs larger).

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