Pathophysiology of Acute Respiratory Distress Syndrome and COVID-19 Lung Injury.

For example, there may be significant variations in pleural pressure in ARDS, especially between dependent and nondependent regions, that are not captured by a point estimate of pleural pressure via esophageal balloon and can be as high as 10 cmH 2 0 in cadaveric studies. 33 Additionally, airway pressure measurements may not accurately estimate local stresses in regions with airway closure, particularly in obese patients. 32 These regional variations in compliance can lead to heterogeneous injury risk.

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