Association of <i>APOE</i> Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease.

Similarly, the APOE ε4 carriers showed a significantly faster decline in MMSE score than the APOE ε3/ε3 group (−3.37 vs −2.97 points per year, 95% CI[−0.79 to −0.01), but a floor effect of the MMSE score became apparent in the APOE ε3/ε3 group, causing APOE ε2 carriers to show a nonsignificant trend toward an apparent faster decline (−3.54 vs −2.97 points per year, 95% CI −1.47 to 0.34).

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