highly significantP <0.0001
At 38 days, when the first animal required euthanasia because of tumor size, tumors were 1,764 ± 1,526 mm 3 in the CA9 group and 126 ± 130 mm 3 in the control group ( Figure 5B ); differences in tumor growth were highly significant ( P <0.0001, twoway repeated measure analysis of variance with the Geisser-Greenhouse correction).