Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.

In HLA-DRB1*0401 transgenics, we confirmed that in the context of a given HLAII heterodimer, the N501Y mutation can result in ablation of this part of the T cell response, demonstrating that HLA polymorphisms are likely to be significant determinants of responder and nonresponder status with respect to vaccine escape.

also in 1,824 other papers