Association of APOE ε4 genotype and lifestyle with cognitive function among Chinese adults aged 80 years and older: A cross-sectional study.

PLoS Med · 2021 · PMC8168868 · PMID 34061824

Europe PMC DOI

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may not be significantno p-value reported

Accordingly, during the early life stage, the difference in cognitive function between APOE ε4 carriers and noncarriers may not be significant, while as people age, APOE ε4 carriers may have a lower average cognitive function compared with noncarriers of the same age due to the cumulative damage of ε4 allele on neurons.

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