Discovery of a cooperative mode of inhibiting RIPK1 kinase.

Reduced doses of either Nec-1s or ( R )-484 alone at 2 mg/kg provided poor protection against SIRS; whereas the mice treated with a combination of ( R )-484 and Nec-1s with each at 1 mg/kg showed statistically highly significant protection against lethality and hypothermia induced by SIRS (Fig. 6e, f ).

also in 132,142 other papers