Genomic and transcriptional alterations in first-line chemotherapy exert a potentially unfavorable influence on subsequent immunotherapy in NSCLC.

Theranostics · 2021 · PMC8171101 · PMID 34093873

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a slightly increasing trendno p-value reported

Although the total number of neoantigens showed a slightly increasing trend after chemotherapy, down-regulated antigen processing and presentation made them could not be recognized by immune system and facilitated the immune escape.

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a decreasing trendno p-value reported

The change in copy number variations (CNVs) exhibited a decreasing trend during chemotherapy.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.